PHARMACOKINETIC DRUG-DRUG INTERACTION AND ITS IMPLICATION IN CLINICAL MANAGEMENT

Harshith B.N,Nagesha.V,AnushaDivakar Naik,M Ajay Kumar,Chaitanya. S, Vandana. C.N, Jahnavi. B.U, Sushmitha Acharya, Samskruthi. N

The adverse drug reactions continue to be significant health concerns in the field of medicine. These reactions impose a significant financial burden on the healthcare system and can severely affect patient outcomes, including life expectancy. Adverse drug reactions appear to be difficult to avoid regardless of circumstances. In light of the introduction of personalized medications along with new biologics, the mechanisms of these adverse drug reactions have become rather complex. Their biological causes are becoming increasingly difficult to determine. That's one reason a different perspective may be,required.This literature review examines the current status of ADRs. This review does not limit itself to the common types A and B reactions. Such adverse drug events as delayed response or withdrawal syndrome can also be considered today. Pharmacogenomics and individual genes of a patient are analyzed by the author in the context of the possible side effects. The patient's age, polypharmacy, comorbidity, and other factors increase the risks for developing side effects in patients. The evolution of pharmacovigilance in terms of the detection of such adverse reactions is also mentioned in this work. Initially, this was based on the passive monitoring of the side effects of medicinal drugs, while today there is a tendency to apply artificial intelligence and big data analysis in the same field.

Keywords –Adverse Drug Reactions; Pharmacogenomics; Pharmacovigilance; Polypharmacy; Drug Safety.